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- Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.
- High doses and long-term use 1 year or longer may increase the risk of osteoporosis -related fractures of the hip, wrist, or spine.
- High doses and long-term use 1 year or longer may increase the risk of osteoporosis -related fractures of the hip, wrist, or spine.
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